Abstract | Kruppel-like factor 5 is a crucial mediator of ...Both mutational inactivation of the adenomatous polyposis coli (APC) tumor suppressor gene and activation of the KRAS oncogene are implicated in the pathogenesis of colorectal cancer. Mice harboring a germline ApcMin mutation or ... Continue reading
The Adenomatous Polyposis Coli-associated Guanine Nucleotide ...Mutation of the tumor suppressor adenomatous polyposis coli (APC) is a key early event in the development of most colorectal tumors. APC promotes degradation of β-catenin and thereby negatively regulates Wnt signaling, whereas mutated ... Continue reading
Peutz-Jeghers News: Mosaicism – What is it? Who's affected? Why ...Somatic APC mosaicism: an underestimated cause of polyposis coli. Gut. 2008 Jan;57(1):71-6. Epub 2007 Jun 29. PMID: 17604324 (6) Farrington SM, Dunlop MG. Mosaicism and sporadic familial adenomatous polyposis. Am J Hum Genet. ... Continue reading
ISPUB - Laparoscopic Total Proctocolectomy For A Case Of Familial ...Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized by multiple adenomatous polyps throughout colon and rectum with 100% risk of malignancy if not operated early. We came across a 32-year-old female patient who, ... The patient's Barium enema revealed polyposis coli. Colonoscopy revealed multiple colonic polyps of varying size with a friable mass lesion in rectum. CT scan showed a 6cm anorectal growth with single perirectal lymph nodes. ... Continue reading
Cyclin A/cdk2 Regulates Adenomatous Polyposis Coli-dependent ...Mutations in adenomatous polyposis coli (APC) protein is a major contributor to tumor initiation and progression in several tumor types. These mutations affect APC function in the Wnt-β-catenin signaling and influence mitotic spindle ... Continue reading
Identification of a Link between the SAMP Repeats of Adenomatous ...The adenomatous polyposis coli (APC) tumor suppressor protein is a multifunctional protein with a well characterized role in the Wnt signal transduction pathway and in cytoskeletal regulation. The SAMP repeats region of APC, ... Continue reading
Adenomatous polyposis coli influences micronuclei induction by ...Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis] Review ... Continue reading
Molecular Insights into Mammalian End-binding Protein ...Fluorescence spectroscopy and nuclear magnetic resonance studies in the presence of the cytoskeleton-associated protein-glycine-rich domains of either CLIP-170 or p150glued or of a fragment derived from the adenomatous polyposis coli ... Continue reading
3,3′-Diindolylmethane Enhances the Efficacy of Butyrate in Colon ...We recently showed that mutations in the adenomatous polyposis coli (APC) gene confer resistance to HDAC inhibitor–induced apoptosis in colon cancers. Here, we show that APC mutation rendered colon cancer cells resistant to ... Continue reading
Dietary-induced ER{beta} upregulation counteracts intestinal ...Most sporadic colorectal cancers (CRCs) develop through the adenoma–carcinoma sequence pathway and are initiated by adenomatous polyposis coli (APC) gene mutations. Estrogen receptor beta (ERβ) is recognized to progressively reduce its ... Continue reading
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